Evaluation of Factors Affecting the Tear-film Lipid Layer Thickness

Yonsei University350 enrolled

Overview

In this study, the investigators aim to determine the effects of age, sex, history of ocular surgery and contact lens use, and ocular surface and meibomian gland parameters on the lipid layer thickness (LLT) in normal subjects and patients with dry eye syndrome. Patients with dry eye syndrome and subjects with a healthy ocular surface will be enrolled. All participant will underwent LLT measurement with a LipiView interferometer, tear meniscus height measurement using optical coherence tomography, tear film break-up time (TBUT) determination, corneal and conjunctival staining, Schirmer's test, examination of the lid margins and meibomian glands, and assessment using the Ocular Surface Disease Index(OSDI) questionnaire.

Study Type

OBSERVATIONAL

Enrollment

350

Conditions

Dry Eye Syndrome

Eligibility

Sex: ALLMin age: 19 YearsMax age: 100 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1\. age over 19 years old, Patients with dry eye syndrome and normal subjects Exclusion Criteria: 1. patients less than 18 years of age and patients with histories of ocular surgery within 3 months; ocular injury; and ocular diseases such as ocular infection, allergy, and autoimmune disease; and patients with the use of a punctal plug or topical ocular medications other than artificial tears. 2. Patients who used artificial tears were instructed not to apply them for at least 12 hours 99 before the examinations

Locations (1)

Outcomes

Primary Outcomes

Tear Lipid Layer thickness measurement with a LipiView interferometer

Time frame: 1 day

Secondary Outcomes

tear meniscus height measurement using optical coherence tomography

Time frame: 1 day

Corneal and conjunctival erosion grade(oxford score)

Time frame: 1 day

tear film break-up time (TBUT)

Time frame: 1 day

Schirmer's test (lacrimal secretion test)

Time frame: 1 day

evaluation of the score of lid margins and meibomian glands

Time frame: 1 day

Ocular Surface Disease Index(OSDI) questionnaire

Time frame: 1 day