The Effects of Anti-infective Central Venous Catheter on Catheter-related Infection in Critically Patients

Inclusion Criteria: * adult patients in intensive care unit (ICU)（age ≥ 18 years） * needs double lumen CVC more than 5 days * Signed informed consent Exclusion Criteria: * thrombosis in target and/or contralateral vein * pregnancy or lactating women * unlikely to survive for more than 1 month * bad prognosis * suspected catheter-related infection * replacement CVC in original site through guide wire * severe burn * situation that is not suitable for CVC, including allergic to CVC material, thrombosis in target vein, infection of puncture site, coagulation disorder, abnormal anatomy * already in this study * participated in other studies within 3 months