Efficacy and Safety of Danggui-Sayuk-Ga-Osuyu-Saenggang-tang on Korean Patients With Cold Hypersensitivity in the Hands

Inclusion Criteria: 1. Female subjects aged 19 to 59 years have a complaint of CHH. 2. Patients must include at least one or more of the following symptoms: * Those who have the symptoms of CHH in normal temperature which most individuals feel no cold; * Those who have the symptoms of extremely cold hands in cold temperature exposure; * Those who are on the return to a warmer environment, the symptoms of cold hands is not completely rewarmed; 3. Those who have 4 cm or greater of VAS CHH score; 4. A thermal differences between the palm (PC8) and the upper arm (LU4) may be higher than 0.3℃; 5. Those who can comply with all study-related procedures, medications, and evaluations; 6. Given a written informed consent form. Exclusion Criteria: We will exclude patients who have taken 1. Patients with calcium antagonists or beta-blockers with the purpose of treating CHH; 2. Those who have one or more finger gangrene or ulceration; 3. Those who are diagnosed by hypothyroidism or currently medicated to thyroid drugs; 4. Those who are diagnosed by autoimmune disease or have a positive ANA test result; 5. Those who are diagnosed by carpal tunnel syndrome or have a positive Tinel and Phalen's tests; 6. Those who are diagnosed with cervical disc herniation or (malignant) tumor disease; 7. Those who are diagnosed with diabetes; 8. Those who are currently medicated to drugs that may affect to CHH symptoms, such as anticoagulants etc; 9. Those who have moderate level of liver dysfunction (each of AST, ALT greater than 100 IU/L) or kidney dysfunction (Cr 2.0mg/dL); 10. Those who do not (cannot) abide by treatment and follow up due to the mental illness such as behavior disorder, depression, anxiety neurosis, schizophrenia, or serious mental illness; 11. Those who are Diagnosed with moderate anemia and hematologic disorders (adult non-pregnant women hemoglobin (Hgb) level less than 7g/dL, hematocrit (Hct) level less than 26%, white blood cell (WBC) level greater than 11,000/mm3); 12. Those whose systolic blood pressure (SBP) 180mmHg or diastolic blood pressure (DBP) is greater than 100 mmHg based on average value of at least 2 measurements; 13. Those who are suspected arrhythmia that showing up on ECG, or diagnosed by heart diseases, such as, ischemic heart disease and so on; 14. Those who are addicted to alcohol or drugs; 15. Those who are pregnant (positive urine-HCG) or lactating or have the chances of pregnancy; 16. Those who are currently participated in other clinical trials; 17. Those who are able to understand and speak Korean; 18. Those who are judged to be inappropriate for the clinical study by the researchers.