Failure to thrive (FTT) is an expression for inadequate growth in the early childhood and thus, a sign of undernutrition. This study will include children with FTT, and compare with existing data from children with normal and excessive growth. The overall aim of this study is to explore whether 1) children who develop FTT with no organic explanation differ from healthy normal weight and overweight children in their basal level of appetite-regulating hormones and 2) if inadequate, normal and excessive growth in children can be partly predicted by variation in their gut microbiome and metabolome.
Study Type
OBSERVATIONAL
Enrollment
45
Hvidovre University Hospital
Hvidovre, Denmark
Appetite-regulating hormones (ghrelin, PYY, leptin) measured by fasting blood samples
Time frame: At subject enrollment
Microbiota composition measured by fecal samples
Time frame: At subject enrollment
Metabolome measured by urine samples
Time frame: At subject enrollment
Metabolic markers (insulin, glucose) measured by fasting blood samples
Time frame: At subject enrollment
Body weight measured in kilograms
Time frame: At subject enrollment
Height measured in centimeters
Time frame: At subject enrollment
Head circumference measured in centimeters
Time frame: At subject enrollment
Waist circumference measured in centimeters
Time frame: At subject enrollment
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