The aim of the study was to describe the relationship between the intensity of a standardized tetanic stimulation and the associated reflex pupillary dilation in patients under ketamine sedation. After an intravenous bolus of 1 mg/kg of ketamine, tetanic stimulations were performed every minute at increasing intensities of 10, 20, 30, 40 and 60 milliamps (similar to the stimulations of neuromuscular blocking agents monitoring). Pupillary diameter was measured before and after each stimulation.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Enrollment
24
bolus 1 mg/kg
10-20-30-40-60 milliamps on the patient's left forearm
Departement d'anesthesie Hopital Armand Trousseau
Paris, France
Pupillary dilation: difference between post- and pre-stimulation pupillary diameter assessed by videopupillometry
Non-invasive measurement of pupillary diameter using an infrared camera, for each of the 6 stimulations per patient
Time frame: 30 seconds after each stimulation (6 stimulations per patient)
Heart rate variation
Time frame: 30 seconds after each stimulation
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