This study assessed the effect of tailored eradication therapy according to Clarithromycin resistance in Helicobacter pylori patients.
This study assessed the effect of tailored eradication therapy according to Clarithromycin resistance in Helicobacter pylori patients. The patients with gastric or duodenal ulcer by endoscopy were registered at the study and inspected Rapid Urease test, Biopsy, IgG-Hp antibody. The tailored eradication therapy was prescribed to patients that confirmed Helicobacter pylori positive in two or more of among the three tests for 14 days. Through this, This study is to assess the effectiveness of eradication rate and to evaluate safety and tolerability of Ilaprazole 10mg qid treatment
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
50
Ilaprazole 10mg 1tablet qid(4 times/day)
Amoxicillin 500mg 1capsule qid(4times/day)
Clarithromycin 500mg 1tablet bid(2times/day)
Eradication rate after tailored therapy assessed by urea breath test
After completion of 14days tailored therapy, the participants will be followed at 4-6 weeks with urea breath test (UBT). The eradication rate will be assessed by the result of UBT.
Time frame: Test at 4 -6 weeks after completion of medication
Number of participants with treatment-related adverse events as assessed by questionnaire
During the medication of tailored therapy, the participants will be asked to check the compliance and adverse events with diary and questionnaire.
Time frame: Questionnaire and diary during medication for 14days
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Metronidazole 250mg 2tablets tid(3times/day)