The purpose of this study is to investigate the correlation between DNA methylation and the treatment and recurrence of oral cancer.
In this study, investigators plan to recruit 40\~50 patients who had, or currently has oral cancer. The study procedures are as below: * After the Informed Consent Form is signed, swab from the lesion site and normal site to obtain oral epithelial cells. * Collect tissue from the tumor site and the non-cancerous matched site from the surgery or the tissue bank. * Collect oral swab from the lesion site and the normal site when patients return to the clinic for a regular follow-up. Specimens will be collected for DNA methylation testing, and the results will be compared with patient's clinical diagnosis. It is expected that the relationship between DNA methylation, oral cancer, and the recurrence of oral cancer will be found.
Study Type
OBSERVATIONAL
Enrollment
46
Taipei Veterans General Hospital
Taipei, Taiwan
Association between the DNA methylation level and the stage of cancer
1. Compare the DNA methylation level and the stage of cancer before treatment. 2. DNA methylation level as a monitor tool for recurrence/metastasis of oral cancer. 3. qPCR will be used to determine the DNA methylation level.
Time frame: 1 year
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.