A Randomized Phase III Study of Adjuvant Chemotherapy With or Without Chemo-radiotherapy in Patients With Local Advanced Gastric Cancer After D2 Resection.

Inclusion Criteria: * Gastric cancer; * D2 and R0 resection; * Pathologically confirmed stage anyT, N+, M0 (AJCC Cancer Staging); * Karnofsky performance score (KPS) \>= 70 or Eastern Cooperative Oncology Group(ECOG) score 0-1; * Adequate blood counts: White blood cell count ≥3.5 x 109/L Haemoglobin levels ≥100g/L Platelet count ≥100 x 109/L Creatinine levels ≤1.0× upper normal limit（UNL） Urea nitrogen levels ≤1.0× upper normal limit（UNL） Alanine aminotransferase(ALT) ≤1.5× upper normal limit（UNL） Aspartate aminotransferase(AST) ≤1.5× upper normal limit（UNL） Alkaline phosphatase(ALP) ≤1.5× upper normal limit（UNL） Total bilirubin(TBIL) ≤1.5× upper normal limit（UNL） * No allergic history of 5-Fu or Platinum drugs; * No history of chemotherapy or other anti-cancer therapy; * Informed consent should be signed. Exclusion Criteria: * GEJ adenocarcinoma * Concomitant malignancies;(except basocellular carcinoma or in-situ cervical carcinoma) * Allergic to Fluorouracil or Platinum drugs; * Concurrent uncontrolled medical condition; * Known malabsorption syndromes or lack of physical integrity of upper gastrointestinal tract; * Severe postoperative complications such as anastomotic leakage, etc.; * Symptoms or history of peripheral neuropathy.