Effect of Dexmedetomidine on Ischemia-Reperfusion Injury in Lower Extremity Operations

Yonsei University68 enrolled

Overview

Ischemia reperfusion injury causes the release of free oxygen radicals. The selective alpha2-receptor agonist, dexmedetomidine, has an inhibitory effect on inflammatory responses during ischemic injury. The aim of this study is to evaluate the effect of dexmedetomidine on inflammatory responses during ischemia-reperfusion injury in skeletal muscle.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

DOUBLE

Enrollment

Conditions

Arthroplasty, Replacement

Interventions

DexmedetomidineDRUG

The dexmedetomidine group received the dexmedetomidine infusion at a rate of 0.4mg/kg/h after a loading dose of 0.5mg/kg for 10 minutes.

normal salineDRUG

The control group received the normal saline infusion

Eligibility

Sex: ALLMin age: 20 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * American Society Anesthesiologists classification I-III Exclusion Criteria: * use of antioxidants clinically significant cardiovascular, renal, or hepatic diseases heart block greater than the first degree

Locations (1)

Severance hospital

Seoul, South Korea

Outcomes

Primary Outcomes

changes of malondialdehyde (μmol/L)

Time frame: up to 1 day

Secondary Outcomes

changes of interleukin-6 (pg/ml)

Time frame: up to 1 day

Data from ClinicalTrials.gov

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