Diagnosis of Macrophage Coronary Plaque by Optical Tomographic Imaging

Young-Hak Kim, MD, PhD20 enrolled

Overview

This study evaluated optimal macrophage diagnosis algorithm through comparative analysis between coronary artery, OCT image, and IVUS, and improve a diagnosis rate of vulnerable coronary plaque accompanied with macrophage infiltration.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Atherosclerotic Plaque

Interventions

The heart subject will undergo OCTPROCEDURE

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Age 18 and above * Patients who are to receive heart transplantation * Patients or their legal representatives who gave a prior written consent Exclusion Criteria: * Impossible to OCT and IVUS analysis due to severe coronary stenosis

Locations (1)

Asan Medical Center

Seoul, Songpa-Gu, South Korea

Outcomes

Primary Outcomes

ROC curve of diagnosis

Receiver Operating Characteristic curve of diagnosis through existing NSD(normalized standard deviation)-based method and developed algorithm in the diagnosis of coronary plaque accompanied with macrophage infiltration

Time frame: within 48 hours

Secondary Outcomes

fibrin accumulation

Time frame: within 48 hours

neoatherosclerosis

Time frame: within 48 hours

elastic lamia

Time frame: within 48 hours

cholesterol crystal

Time frame: within 48 hours

microcalcification

Time frame: within 48 hours

Data from ClinicalTrials.gov

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