Study of the Effects of Intravenous Exenatide on Cardiac Repolarization

Inclusion Criteria: * Body mass index (BMI) between 19 to 35 kg/m2 inclusive. * Women of child bearing potential - use of an additional adequate method of contraception during the study and until 1 additional menstrual cycle following the end-of-study (EOS) visit. Adequate methods of contraception for women of child bearing potential (WOCBP) include: mechanical products (ie, intrauterine device \[IUD\]-copper IUD); or barrier methods (eg, diaphragm, condoms, cervical cap) with spermacide. * Aspartate aminotransferase (AST), alanine aminotransferase (ALT), alkaline phosphatase (AP), and bilirubin within normal range at Screening. * Fasting triglycerides within the normal range at Screening Exclusion Criteria: * History of type 1 or type 2 diabetes, or history of hypoglycemia. * History or evidence of myocardial infarction, congestive heart failure, syncope not related to heart arrhythmia, coronary revascularization (coronary artery bypass grafting or percutaneous coronary intervention), unstable angina, or cerebrovascular accident or stroke or TIA. * History of atrial fibrillation, flutter, or non-sustained or sustained VT. * Personal or family history of sudden death or long QT syndrome. * History of uncontrolled hypertension. * History or evidence of acute or chronic pancreatitis. * History of liver disease. * Abnormal renal function. * History of medullary thyroid cancer or a personal or family history of multiple endocrine neoplasia type 2. * Thyroid-stimulating hormone (TSH) outside of normal limits at Screening . * Weight loss surgery. * History of malignancy (not including basal or squamous cell carcinoma of the skin with past 5 years). (Subjects who have been disease free for greater than 5 years may be included.) * History of active alcohol within 1 year prior to Screening. * History of drug abuse within 5 years prior to Screening or a positive prestudy drug screen. * Weekly consumption of more than 14 alcoholic beverages for females and more than 21 alcoholic beverages for males. * Smoke more than 10 cigarettes per day. * Excessive in xanthine consumption (more than 5 cups of coffee or equivalent per day). * History of hypersensitivity to any of the medications used in this study. * Women that are pregnant, lactating, or planning to become pregnant. * History of or positive results on screening tests for hepatitis B and/or hepatitis C and/or human immunodeficiency virus (HIV). * History or evidence of immunocompromised status. * Prior or current treatment with any GLP-1 receptor agonist (eg, Bydureon™, Byetta®, Victoza®, Tanzeum® or exogenous native GLP-1) or prior participation in an ITCA 650 clinical trial. * Any gastrointestinal complaints within 7 days prior to first dosing. * Use of medications within 14 days of first dose other than hormone replacement therapy and oral contraceptives. * Chronic (8 consecutive days or greater) treatment with systemic corticosteroids.