BPM31510 Administered Intravenously With Gemcitabine in Advanced Pancreatic Cancer Patients

Inclusion Criteria: * The patient has a histologically or cytologically confirmed metastatic pancreatic adenocarcinoma. * The patient has undergone at least one prior, but no more than 2 prior standard, therapies for pancreatic cancer.If the patient has had prior gemcitabine treatment, the last date of gemcitabine administration-should be \> 3 months prior to screening for the study. All patients who have previously received gemcitabine should be discussed with the medical monitor during screening * The patient is at least 18 years old. * The patient has an Eastern Cooperative Oncology Group (ECOG) performance status * Measurable tumor lesions according to RECIST 1.1 criteria (Section 10.2). * In the opinion of the Investigator, the patient has a life expectancy of \> 3 months. * Sexually active patients and their partners agree to use an accepted method of contraception during the course of the study (Appendix C:Guidelines Regarding Women of Childbearing Potential). * Female patients of childbearing potential must have a negative pregnancy test within 1 week prior to beginning study treatment. * The patient has adequate organ and marrow function as follows: * absolute Neutrophil Count (ANC) ≥ 1500 mm3, platelets ≥ 100,000/mm3, hemoglobin ≥ 9 g/dL, * serum creatinine \< upper limit of normal (ULN); * total bilirubin \< 1.5 X (ULN) ; alanine aminotransferase (ALT), aspartate transaminase (AST) ≤ 2.5 times the upper limit of normal (ULN) if no liver involvement or ≤ 5 times the upper limit of normal with liver involvement. * The patient has serum electrolytes (including calcium, magnesium, phosphorous, sodium and potassium) within normal limits (supplementation to maintain normal electrolytes is allowed). * The patient has adequate coagulation: prothrombin time (PT) and an International Normalized Ratio (INR), and partial thromboplastin time (PTT) ≤ 1.5 times the upper limit of normal (ULN), * In the opinion of the Investigator, the patient is capable of understanding and complying with the protocol and has signed the informed consent document. Exclusion Criteria: * The patient has uncontrolled intercurrent illness including, but not limited to uncontrolled infection, symptomatic congestive heart failure (NYHA class III and IV), uncontrolled cardiac arrhythmia, or psychiatric illness/social situations that would limit compliance with study requirements. * The patient has active heart disease including myocardial infarction within previous 3 months, symptomatic coronary artery disease, arrhythmias not controlled by medication, unstable angina pectoris, or uncontrolled congestive heart failure (NYHA class III and IV). * The patient has received chemotherapy or radiotherapy within 4 weeks or has received nitrosoureas or mitomycin C within 6 weeks prior to the first dose of study drug. * The patient has received radiation to ≥ 25% of his or her bone marrow within 4 weeks of the first dose of study drug. * The patient has received an investigational drug within 30 days of the first dose of study drug. * Evidence of central nervous system (CNS) metastasis (negative imaging study, if clinically indicated, within 4 weeks of Screening Visit). * History of other malignancies (except adequately treated Stage 1 cancer, cured basal cell carcinoma, superficial bladder cancer, Breast ductal carcinoma in situ (DCIS), or carcinoma in situ of the cervix) unless documented free of cancer for ≥5 years. * The patient has not recovered to grade ≤ 1 from adverse events (AEs) due to investigational drugs or other medications, which were administered more than 4 weeks prior to the first dose of study drug. * The patient is pregnant or lactating. * The patient is known to be positive for the human immunodeficiency virus (HIV). The effect of BPM31510 on HIV medications is unknown. Note: HIV testing is not required for eligibility, but if performed previously and was positive, the patient is ineligible for the study. * The patient has an inability or unwillingness to abide by the study protocol or cooperate fully with the Investigator or designee. * The patient is receiving digoxin, digitoxin, lanatoside C or any type of digitalis alkaloids. * The patient has uncontrolled or severe coagulopathies or a history of clinically significant bleeding within the past 6 months, such as hemoptysis, epistaxis, hematochezia, hematuria, or gastrointestinal bleeding. * The patient has a known predisposition for bleeding such as von Willebrand's disease or other such condition. * The patient requires therapeutic doses of any anticoagulant, including low molecular weight heparin (LMWH). Concomitant use of warfarin, even at prophylactic doses, is prohibited.