Efficacy of Ketamine for Improvement in Postoperative Pain Control After Spinal Fusion for Idiopathic Scoliosis

Albany Medical College50 enrolled

Overview

This study hypothesizes that the addition of a low-dose ketamine infusion to usual post-operative pain management will improve pain control as evidenced by an improvement in post-operative pain scores for patients undergoing spinal fusion for idiopathic scoliosis.

After consenting, patients will be randomized by the pharmacy. In the operating room patients will receive ketamine/placebo 0.5mg/kg bolus prior to the surgical incision, followed by ketamine/placebo 0.2mg/kg continuous infusion up to 48hours. All the patients will also receive 15mg/k IV acetaminophen at the end of the surgery, followed by every 6hr for 48hrs. Rest of the pain regimen will be the usual post-operative pain management for spinal fusion for idiopathic scoliosis, which includes morphine PCA, IV ketorolac from POD 1, and flexaril from POD 1. All the patients and parents will fill out a survey at 0hr, 24hr and 48hr grading their level of satisfaction with the post-operative pain.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

TRIPLE

Enrollment

Conditions

Idiopathic Scoliosis Post-operative Pain

Interventions

KetamineDRUG

PlaceboOTHER

Eligibility

Sex: ALL

Medical Language ↔ Plain English

Inclusion Criteria: * ASA I, II, III * Presenting for spinal fusion for idiopathic scoliosis * English-speaking and able to give assent Exclusion Criteria: * Any contraindication to ketamine * Previous spinal surgery * Opioid dependence * Chronic pain condition * Significant developmental delay * Pregnancy

Locations (1)

Albany Medical Center

Albany, New York, United States

Outcomes

Primary Outcomes

Patient Satisfaction

All the patients and parent will fill out a survey grading their level of satisfaction with their post-operative pain management. Patient Satisfaction Score from a scale of 1 - 4 was used - 1. Unsatisfied 2. Moderately satisfied 3 - Generally satisfied 4 - Very satisfied No other subscales were included.

Time frame: Through study completion, 48 hours

Secondary Outcomes

Pain Score

Pain scores will be collected from the nursing sheet. Pain score was measured using "self-rating numeric scale" a scale from 1 to 10, where 1 is minimum pain and 10 is maximum pain. No other subscales were done.

Time frame: Through study completion 48 hours

Opioid Use

Total Morphine consumption will be collected from Patient Controlled Analgesia (PCA) morphine pump. The secondary outcome measure was total morphine consumption difference in 48hrs.

Time frame: Through study completion, 48 hours

Length of Stay

Length of hospital stay from surgery to discharge

Time frame: Through study completion, 48 hours

Data from ClinicalTrials.gov

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