This study will evaluate the effect of a fully closed loop ventilation mode (Intellivent ASV) on the duration of ventilation compared to conventional modes in COPD patients.
COPD patients often need invasive mechanical ventilation and due to the difficulties in the weaning of these patients, duration of mechanical ventilation can be relatively longer when compared with other ICU patients. Automated systems show promising results in shortening the weaning time in some patient groups. The aim of this study is to evaluate the effect of Intellivent-ASV with Quickwean function on the total duration of invasive mechanical ventilation as a primary outcome. Secondary outcomes are success rate and duration of weaning, ventilator free days at day 28 and intubation free days at day 28 (including NIV) when compared to conventional ventilation with t-piece weaning.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
88
Automated Invasive mechanical ventilation and weaning strategy
Izmir Dr Suat Seren Chest Diseases and Surgery Education and Research Hospital, Intensive Care Unit
Izmir, Turkey (Türkiye)
Duration of intubation
Time from intubation until extubation
Time frame: 24th month
Duration of mechanical ventilation (NIV included)
Total time patient remains on mechanical ventilation support (invasive or noninvasive)
Time frame: 24th month
Number of manual settings
Number of adjusments made manually to set the ventilator
Time frame: 24th month
Number of blood gas analysis tests
Number of arterial blood gas tests under mechanical ventilation
Time frame: 24th month
Weaning duration
Time from the beginning of weaning until extubation
Time frame: 24th month
Time spent on spontaneous ventilation
Time patient actively triggers the ventilator
Time frame: 24th month
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