Nasal Swab studyComparison of Effectiveness of Povidone-iodine Versus Saline Versus 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP Swabs for Decolonizing Intranasal MSSA/MRSA

Rothman Institute Orthopaedics

Overview

To determine if routinely available 10% povidone-iodine swabs are more effective than saline and 3M Skin and Nasal Antiseptic 5% Povidone-Iodine USP for decolonizing MRSA.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

SCREENING

Masking

NONE

Conditions

MRSA/ MSSA Colonization of the Nares

Interventions

SalineDRUG

Povidone-IodineDRUG

5% Povidone-Iodine USP swabsDRUG

Eligibility

Sex: ALLMin age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: 1. All potential total hip and total knee arthroplasty candidates 2. All femoroacetabular osteoplasty patients 3. All pelvic acetabular osteotomy patients 4. All core decompression patients Exclusion Criteria: 1. Any trauma patients 2. Any tumor patients 3. Any patient with periprosthetic joint infection 4. Any patient with surgical site infection 5. Any patient with known MRSA infection 6. Any patients allergic to povidone-iodine 7. Patients with thyroid disease

Outcomes

Primary Outcomes

MSSA/MRSA colonization in the nares

Subjects will undergo a swab of their nares to undergo PCR analysis to determine if they are effectively decolonized four hours after initial treatment

Time frame: 4 hours

MSSA/MRSA colonization as tested by PCR

Subjects will undergo a swab of their nares to undergo PCR analysis to determine if they are effectively decolonized four hours after initial treatment

Time frame: 24 hours

Data from ClinicalTrials.gov

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