Dexmedetomidine and Ketamine in MRI

Children's Hospital Medical Center, Cincinnati22 enrolled

Overview

The purpose of this research study is to examine the effects of two commonly used anesthetic drugs, dexmedetomidine and ketamine, have on the shape and muscle tone of the upper airway in children, adolescents, and young adults. The results of this study will help in making the best decisions regarding the anesthesia medications used for sedation outside of the operating room.

Upper airway obstruction is a common problem in spontaneously breathing patients under anesthesia. This study is examining the effects of combining dexmedetomidine and ketamine on the muscle tone and airway configuration in children under anesthesia. The hypothesis is adding ketamine to dexmedetomidine will not significantly reduce airway caliber or morphology when compared to previously collected data using dexmedetomidine alone.

Study Type

INTERVENTIONAL

Allocation

Purpose

OTHER

Masking

NONE

Enrollment

Conditions

Magnetic Resonance Imaging

Interventions

DexmedetomidineDRUG

2 mc/kg/h over ten minutes followed by a continuous infusion of 2 mcg/kg/h

KetamineDRUG

Bolus dose 2 mg/kg after first set of research images are obtained

Eligibility

Sex: ALLMin age: 1 YearMax age: 18 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient requires anesthesia for a MRI scan of the brain or MRI brain/spine * Patient must be 1 to 18 years of age * Patients legally authorized representative has given written informed consent to participate in the study Exclusion Criteria: * Allergy to dexmedetomidine or ketamine * History or obstructive sleep apnea * The patient has a life-threatening medical condition (ASA status 4, 5, or 6) * The patient is not scheduled to receive anesthesia sedation for the MRI * Patient has a history or a family history of malignant hyperthermia

Locations (1)

Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, United States

Outcomes

Primary Outcomes

Measurement of soft palate under anesthesia

MRI images for research will be taken 4 times during the MRI; estimated additional 6 minutes will be added to the MRI scan