Enchanced recovery after surgery (ERAS) protocols aim to provide safer and quicker recovery postoperatively. One of the elements in ERAS protocols is that bowel is not prepared before colorectal surgery. However, several recent retrospective register studies have suggested that mechanical bowel preparation combined to oral antibiotics before colectomy reduces complications compared to no preparation at all. This trial compares these two strategies to find out whether complications can indeed be reduced by mechanically preparing the bowel with oral antibiotics.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Enrollment
417
Helsinki University Central Hospital
Helsinki, Finland
Central Finland Central Hospital
Jyväskylä, Finland
Oulu University Hospital
Oulu, Finland
Seinäjoki Central Hospital
Seinäjoki, Finland
Surgical site infection (CDC criteria)
Time frame: 30 days from operation
Comprehensive Complication Index
Time frame: 30 days from operation
Anastomotic dehiscence
Time frame: 30 days from operation
Reoperations
Time frame: 30 days from operation
Readmissions
Time frame: 30 days from operation
Length of hospital stay
Time frame: During hospital stay, anticipated 2-30 days
Mortality
Time frame: 30- and 90-days from operation
Adverse effects of antibiotics (diarrhea, clostridium)
Time frame: 30 days from operation
Patients receiving adjuvant therapy divided by patients needing adjuvant therapy
Time frame: 6 months from operation
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