Beneficial Effect of Xylose Consumption on Postprandial Hyperglycemia

Yonsei University80 enrolled

Overview

The present study determined the effect of Xylose consumption on postprandial hyperglycemia in normal (n=25) and hyperglycemic subjects (n=50).

In this double-blind crossover designed study, Participants were randomly assigned to consume a sucrose drink (Control, sucrose 50g + deionized water 100g) or a sucrose drink additionally containing 5 g (Test 1, sucrose : xylose = 10:1), 3.33 g (Test 2, sucrose : xylose = 15:1) or 2.5 g (Test 3, sucrose : xylose = 20:1) of D-xylose with a week interval.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Postprandial Hyperglycemia

Interventions

Test 1DIETARY_SUPPLEMENT

sucrose : xylose = 10:1, sucrose 50 g + xylose 5 g + deionized water 95 g

Test 2DIETARY_SUPPLEMENT

sucrose : xylose = 15:1, sucrose 50 g + xylose 3.33 g + deionized water 96.67 g

Test 3DIETARY_SUPPLEMENT

sucrose : xylose = 20:1, sucrose 50 g + xylose 2.5 g + deionized water 97.5 g

Eligibility

Sex: ALLMin age: 20 YearsMax age: 70 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1\) healthy subject or Impaired fasting glucose (fasting serum glucose between 100 and 125 mg/dL) Exclusion Criteria: 1. history of taking an insulin-injection or oral hypoglycemic agents 2. evidence of alcohol abuse or alcoholism 3. pregnancy or breast feeding 4. chronic gastrointestinal disorder 5. seriously abnormal liver or renal function 6. an occupation at risk of death when hypoglycemia occurs

Outcomes

Primary Outcomes

Change of serum glucose levels

Time frame: a week interval

Secondary Outcomes

Change of serum insulin levels

Time frame: a week interval

Change of serum C-peptide levels

Time frame: a week interval

Data from ClinicalTrials.gov

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