Is Routine Use of Histopathological Examination Necessary After Cholecystectomy ?

Sisli Hamidiye Etfal Training and Research Hospital1,000 enrolled

Overview

Cholecystectomy has been made with benign conditions usually. The aim of this study is to compare the macroscopic evaluations of the cholecystectomy specimens with it's histopathological examinations.

Cholecystectomy is one of the most frequently performed surgery in the world and often made with benign conditions. Routinely cholecystectomy specimens sent for histopathologic examination. The histopathologic examination of the cholecystectomy specimens are benign in most of the cases and the incidental malignancy of the gallbladder is 2-2.9% in the literature. The histopathologic evaluations of the gallbladder come with additional workload for pathology and surgery departments. Also there is additional cost for the patients. Because of that the idea of selective histopathologic examination has been raised.

Study Type

OBSERVATIONAL

Enrollment

1,000

Conditions

Cholelithiasis

Eligibility

Sex: ALLMin age: 18 YearsMax age: 80 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Subject has cholelithiasis Exclusion Criteria: * Subject has acute cholecystitis * Subject has perforated gallbladder * Subject has malignancy * Subject has polyps in the gallbladder * Subject has increasing wall thickness of the gallbladder * Subject has malignancy in the preoperative ultrasonography in the gallbladder * Subject has pregnancy

Locations (6)

Bursa Yuksek Ihtisas Training and Research Hospital

Bursa, Turkey (Türkiye)

Erzincan University

Erzincan, Turkey (Türkiye)

Bezmialem Vakif University

Istanbul, Turkey (Türkiye)

Sisli Etfal Training and Research Hospital

Istanbul, Turkey (Türkiye)

Outcomes

Primary Outcomes

The comparison of macroscopic and histopathologic examination of the cholecystectomy specimen with 1000 cases

The 1000 cholecystectomy specimens will be evaluated macroscopically by two experienced surgeons with a longitudinal incision to the gallbladder. The specimens will be grouped as benign, suspicious, malign according to the surgeon's decision. To confirm the surgeon's macroscopic evaluation, all of the specimens will be evaluated histopathologically. The results of macroscopic and histopathological examinations will be compared.

Time frame: 15 days

Data from ClinicalTrials.gov

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