Effect of Raltegravir in Patients With Acute Tropical Spastic Paraparesis - Human T-Lymphotropic Virus 1 Infection

Inclusion Criteria: * human t lymphotrophic virus 1 confirmed * Tropical Spastic Paraparesis of recent onset (less than 4 years) Exclusion Criteria: * Pregnant or breastfeeding or unwilling to use contraception. * Treatment with immunosuppressive, immunomodulatory or experimental treatments within the last 6 months of enrolment in the study. * Patients presenting with medical disorder such as poorly controlled diabetes or arterial hypertension, severe cardiac insufficiency, unstable ischemic heart disease, abnormal liver function tests (\>2.5 times upper limit normal (ULN)) and abnormal complete blood count (in particular leukopenia, as defined by a lymphocyte count \<500, neutrophil \<1.5 or platelet count \< 100, or thrombocytopenia \< 1.5 low limit normal (LLN), or any medical condition which, in the opinion of the chief investigator, would pose additional risk to the patient. * Presence of human immunodeficiency virus antibodies. * Patients with active hepatitis B or/and C with liver function tests \>2.5 times ULN * Exposure to any other investigational drug within 30 days of enrolment in the study.