Dose Escalating Study of Foxy-5 in Breast-, Colon- or Prostate Cancer Patients

Inclusion Criteria: * Males and females of at least 18 years of age * Histologically/cytologically documented diagnosis of metastatic breast, colon or prostate cancer, refractory to standard therapy or for which no curative therapy exists * Must have an evaluable tumour appropriate for biopsy as determined by the Investigator. * Loss of or reduced Wnt-5a protein expression in primary or metastatic tumour cells, characterised by IHC analysis * Eastern Cooperative Oncology Group (ECOG) performance status of \<= 1 * Life expectancy of at least 3 months * Unresectable disease, i.e. the metastases cannot be surgically removed with a curative intent * 4 weeks must have elapsed since the patient has received any other IMP * 4 weeks must have elapsed since the patient has received any anti cancer treatment; including radiotherapy (except for single dose of palliative radiotherapy), cytotoxic chemotherapy, biologic agents or targeted therapy * 2 weeks must have elapsed since any prior surgery or therapy with bone marrow stimulating factors * Adequate haematological functions as defined by: * Absolute neutrophil count \>= 1.5 10E9/L * Platelets \>= 100 10E9/L * Hemoglobin \>= 5.6 mmol/L * Adequate hepatic function as defined by: * Total bilirubin \<= 1.5 x the upper limit of normal (ULN) * Aspartate aminotransferase (AST) \<= 2.5 x ULN\* * Alanine aminotransferase (ALT) \<= 2.5 x ULN\* * For patients with liver metastasis adequate hepatic function is defined by AST \<= 5 x ULN and ALT \<= 5 ULN. * Adequate renal function as defined by Serum creatinine \<= 1,5 x ULN * Patients in active anti-coagulating treatment must be evaluated according to local standards on the discretion of the Investigator.. * Provision of written informed consent * Willingness and ability to comply with scheduled visits, treatment plans, laboratory tests and other study procedures * Sexually active males and females of child-producing potential, must use adequate contraception (intrauterine devices, hormonal contraceptives (contraceptive pills, implants, transdermal patches, hormonal vaginal devices or injections with prolonged release) or diaphragm always with spermicidal jelly and a male condom) for the study duration and at least six months afterwards Exclusion Criteria: * Active uncontrolled bleeding or bleeding diathesis (e.g., active peptic ulcer disease) * Any active infection requiring antibiotic treatment * Known infection with human immunodeficiency virus (HIV) or hepatitis virus * Active heart disease including myocardial infarction or congestive heart failure within the previous 6 months, symptomatic coronary artery disease, or symptomatic arrhythmias currently requiring medication * Known or suspected active central nervous system (CNS) metastasis. (Patients stable 8 weeks after completion of treatment for CNS metastasis are eligible) * Impending or symptomatic spinal cord compression or carcinomatous meningitis * Requiring immediate palliative surgery and/or radiotherapy(except for a single dose of palliative radiotherapy) * Pre-existing neuropathy, i.e., Grade \>2 neuromotor or neurosensory toxicity * Participation in other clinical studies within 4 weeks of first dose of study treatment * Previous exposure to Foxy-5 * History of severe allergic or hypersensitive reactions to excipients * Pregnant or breastfeeding women * Active and/or within the last 5 years histologically confirmed diagnosis of malignant melanoma, gastric cancer, pancreatic cancer, lung cancer or nasopharyngeal cancer * Severe or uncontrolled chronic or uncontrolled systemic disease (e. g. severe respiratory or cardiovascular disease) * Other medications or conditions that in the Investigator's opinion would contraindicate study participation of safety reasons or interfere with the interpretation of study results