Recently, a special emphasis has recently been directed to the potential role of vitamin D and some regulatory peptides (e.g. adipokines and follistatin) and their associated metabolic roles and genetic factors in the development of PCOS and its related co-morbidities. The aim of this study was to assess the feasibility of conducting a pragmatic RCT assessing the effectiveness of adopting a protocol of screening for and correcting Vitamin D deficiency in women with PCOS seeking fertility treatment in a low/middle income care (LMIC) setting
Research question: In PCOS patients, is there any effect of vitamin D testing and correction on ovulation induction in women with PCOS? Research hypothesis: There is effect of testing and correcting vitamin D status as regard ovulation in patients with PCOS
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Enrollment
300
6000 IU of vitamin D3
only Clomophine Citrate
Faculty of Medicine, Ain Shams University
Cairo, Cairo Governorate, Egypt
cumulative clomiphene citrate-induced ovulation rates
Ultrasound Folliculometry was performed every other day starting on the 10th day of the induction cycle. Until, at least, one follicle reached 18mm in diameter
Time frame: 6 months
Cumlative clinical pregnancy rate
detection of fetal heart activity detected by transvaginal ultrasound
Time frame: 6 months
median ovulating dose of clomiphene citrate
Dose required
Time frame: 6 months
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