Small Bowel Endoscopic Evaluation in Familial Adenomatous Polyposis (FAP)

University of Sao Paulo55 enrolled

Overview

Background and study aim The relative risks of duodenal adenocarcinoma and ampullary carcinoma in Familial Adenomatous Polyposis (FAP) have been estimated 100 to 330 times higher than in general population. However risk factors, including a genotype-phenotype association for duodenal cancer in FAP has not been fully understood. The aim of this study is to determine risk factors associated with the development of advanced duodenal polyposis and ampullary adenomas in colectomized patients with FAP.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Familial Adenomatous Polyposis

Interventions

Duodenoscopy and enteroscopyPROCEDURE

All patients will undergo duodenoscopy and classified according to Spigelman. Patients classified as Spigelman III and IV will undergo enteroscopy.

Molecular analysis.GENETIC

DNA analysis

Eligibility

Sex: ALLMin age: 15 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with Familial Adenomatous Polyposis with colectomy, or scheduled for surgery. Exclusion Criteria: * Pregnancy, lactation

Locations (1)

University of Sao Paulo Medical School

São Paulo, Brazil

RECRUITING

Outcomes

Primary Outcomes

Genetic profile in FAP patients

Time frame: one year

Central Contacts

Marianny Sulbaran, MD

CONTACT

5511 948526841 mariannysulbaran@gmail.com

Data from ClinicalTrials.gov

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