The present randomized, controlled, parallel-grouped trial included twenty patients (aged 20 to 54 years) suffering from Miller's class I or II gingival recession. Patients were randomly assigned into two equal groups; control group; the coronally advanced flap with the subepithelial connective tissue graft (CAF+SCTG) or the test group; coronally advanced flap with amnion chorion allograft membrane (CAF+AC).
The participants were randomly assigned to receive coronally advanced flap (CAF) with amnion chorion membrane or CAF with subepithelial connective tissue graft using a simple randomization procedure with a 1:1 allocation ratio. A computer generated randomization list was drawn up by a faculty member who was not involved in the recruitment. Allocation concealment was achieved by sealed coded opaque envelopes that contained the treatment to be performed to the enrolled subjects based on the randomized numbers. Consequently, patients were allocated to either AC membrane (intervention) or SCTG (control) groups. The sealed envelope containing treatment assignment was opened at time of the surgery and the number was picked by another person other than the operator.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
20
Biologic Amnion chorion allograft membrane derived from placenta of a donor pregnant subject.
coronally advanced flap with the placement of subepithelial connective tissue graft harvested from the palate
recession depth
It is measured as the distance from the cemento-enamel junction to the gingival margin representing the amount of root coverage.
Time frame: Change in mm from baseline before surgical procedure to follow up at 6 months.
Recession Width
It is measured as the distance from mesial and distal papillae along cemento-enamel junction.
Time frame: Change in mm from baseline before surgical procedure to follow up at 6 months.
Width of keratinized gingiva
It is measured from the mucogingival junction to the free gingival margin.
Time frame: Change in mm from baseline before surgical procedure to follow up at 6 months.
Probing pocket depth
It is measuring the distance from the base of pocket to the gingival margin.
Time frame: Change in mm from baseline before surgical procedure to follow up at 6 months.
Clinical attachment level
It is measuring the distance from the apical end of periodontal probe to cemento-enamel junction.
Time frame: Change in mm from baseline before surgical procedure to follow up at 6 months.
Tissue Biotype
It is measured by penetrating the gingiva with the periodontal probe down to bone after giving local anesthesia to measure the thickness of gingival tissues
Time frame: Change in mm from baseline before surgical procedure to follow up at 6 months.
root coverage esthetic score
The clinical esthetic evaluation was performed without magnification to evaluate gingival margin, marginal tissue contour, soft tissue texture, mucogingival junction alignment and gingival color
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Time frame: score taken after completion of the study at 6 months
Patient reported outcomes
Patients were given certain questions regarding not regretting to perform the surgery, root hypersensitivity and aesthetic satisfaction to be answered at the 6 month follow-up for assessing their satisfaction with the whole procedure.
Time frame: taken after completion of the study at 6 months