This is a sample made up of ninety-six adult individuals of both sexes to be divided into three groups: the experimental group of thirty-two patients with OCD who will be undergone Trial-Based Cognitive Therapy; the gold standard, with thirty-two people with OCD subject Exposure and Response Prevention and the control group of thirty-two healthy individuals. Interviews and therapeutic intervention occur in private practices researchers or medical schools accredited by UESPI. Experimental group: Will be eligible adults of both sexes with educational level equal to or higher education complete primary, aged between 18 and 60 years with OCD diagnosis confirmed according to criteria DSM-IV (APA, 1994). It is going to be excluded patients who had previously undergone treatment behavioral psychotherapy or cognitive-behavioral approach.
OBJECTIVES Evaluate the effectiveness of Trial-Based Cognitive Therapy (TBCT) compared to Exposure and Response Prevention (ERP) in the treatment of OCD patients, by neuroimaging tests such as MRI. 1. Describe the neuroanatomical profile of the sample participants before and after the psychotherapeutic intervention by MRI; 2. Compare the profile neuroanatomical between the experimental group and the control group by MRI; 3. Identify possible neuroanatomical differences in the participating sample of pre and post-treatment, both among individuals and among psychotherapeutic intervention groups; 4. To investigate associations between the results of MRI scans and indexes the scales currently used to assess severity of OCD.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
96
Trial-Based Cognitive Therapy (TBCT) is a three-level, three-phase, case formulation approach. TBCT's foundation is in cognitive therapy (CT); however, it has a unique approach to conceptualization and techniques that make it a distinct intervention in modifying patients' core beliefs, especially those about the self. All the individuals will be submitted to MRI.
The Behavioral therapy employs the technique of Exposure and Response Prevention ( ERP ).The technique involves directly exposing patients to recall stimulation of obsessive thoughts and prevent them from performing the compulsive rituals. All the individuals will be submitted to MRI.
Piauí State University - UESPI
Teresina, Piauí, Brazil
The severity of OCD (Morphological and physiological changes in the brain)
Data colected at 1st week, 6th week, 12th week. Scales used are Yale-Brown Obssessive Compulsive Scale and Symptoms of Checklist (Y-BOCS), Beck Depression Inventory (BDI), Beck Anxienty Inventory (BAI), Obsessive-Compulsive Beliefs Questionnaire-87 (OBQ-87), The Medical Outcomes Study 36 - Item Short Form Health Survery ( SF-36), Questionnare of Cognitive Distortions (CD-Quest), Subjective Units of Discomfort (SUDS) and MRI.
Time frame: 12 weeks (3 months)
Quality of Life
Data colected at 1st week and 12th week and, at follow-up, after three months, six months and one year. The scale used is SF-36
Time frame: 12 weeks
Quality of Life
At follow-up, after three months, six months and one year. The scale used is SF-36
Time frame: 1 year
Cognitive Distortions
Data colected every week (during 12 weeks). The scale used is CD-Quest
Time frame: 12 weeks
Cognitive Distortions
At follow-up, after three months, six months and one year. The scale used is Cognitive Distortions Questionnaire.
Time frame: 1 year
Severity of OCD
Data colected at 1st week, 6th week and 12th week and, at follow-up, after three months, six months and one year. The scale used is Y-BOCS
Time frame: 12 weeks
Severity of OCD
At follow-up, after three months, six months and one year. The scale used is Y-BOCS.
Time frame: 1 year
The Assessment of Depression
Data colected at 1st week, 6th week and 12th week and, at follow-up, after three months, six months and one year. The scale used is BDI
Time frame: 12 weeks
The Assessment of Depression
At follow-up, after three months, six months and one year. The scale used is BDI
Time frame: 1 year
The Assessment of Anxiety
Data colected at 1st week, 6th week and 12th week and, at follow-up, after three months, six months and one year. The scale used is BAI
Time frame: 12 weeks
The Assessment of Anxiety
At follow-up, after three months, six months and one year. The scale used is BAI
Time frame: 1 year
The Assessment of Magnetic Resonance (MRI)
Data colected at zero week and 15th week. The scale used is MRI
Time frame: 15 weeks
The Assessment of The Obssessive Beliefs
Data colected at zero week and 15th week. The scale used is OBQ-87
Time frame: 15 weeks
The level of Anxiety (Obssessive, Compulsive and Evitation Symptoms)
Data colected every week (during 12 weeks). The scale used is SUDS
Time frame: 12 weeks
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