Can a fetal bovine derived membrane serve as an alternative to autogenous tissue for dental root coverage procedures.
PriMatrix (TEI Medical Inc) is a promising collagen membrane derived from fetal bovine dermis. The acellular porous structure of the membrane permits rapid re-vascularization and cellular re-population. The membrane contains a high proportion of type III collagen. Type III collagen helps regulate tissue healing by promoting neoepithelialization and angiogenesis. Wounds grafted with PriMatrix exhibited significantly faster healing rates compared to control wounds while having a minimal foreign body response and early repopulation by progenitor cells. The ability of PriMatrix to permit neovascularization, reepithelialization, minimal immune response, and population by progenitor cells suggests that it may serve as an ideal alternative to CTG under CPF for root coverage. In this regard, the current study aims to serve as a pilot to test the feasibility of the use of PriMatrix as a graft material under a CPF to attain root coverage of Miller Class I \& II defects.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
12
Use of PriMatrix under a coronal positioned flap to obtain root coverage.
Mayo Clinic in Rochester
Rochester, Minnesota, United States
Complete Root Coverage
The percentage of sites showing complete root coverage will be calculated as a percent of treated defects with the marginal gingival located at or above the cement-enamel junction compared to the total defects treated.
Time frame: 6-months
Clinical Periodontal Parameters
Determine keratinized tissue width of the augmented region using a UNC-15 mm periodontal probe.
Time frame: Baseline, 6-weeks, 4-months, and 6-months
Clinical Periodontal Parameters
Determine periodontal probing depths of the augmented region using a UNC-15 mm periodontal probe.
Time frame: Baseline, 6-weeks, 4-months, and 6-months
Clinical Periodontal Parameters
Determine tissue thickness of the augmented region using a UNC-15 mm periodontal probe.
Time frame: Baseline, 6-weeks, 4-months, and 6-months
Clinical Periodontal Parameters
Determine clinical attachment levels of the augmented region using a UNC-15 mm periodontal probe.
Time frame: Baseline, 6-weeks, 4-months, and 6-months
Pain Levels
Visual analog scale questionnaire will be completed consisting of 5 to 6 questions at each appointment.
Time frame: 1-week, 2-weeks, 4-weeks, and 6-months
Mean Root Coverage Obtained
Percentage of baseline root coverage obtained as a fraction of initial recession depth will be measured using a UNC-15 mm periodontal probe.
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Time frame: Baseline, 6-weeks, 4-months, and 6-months
Gingival Health
Gingival health will be evaluated visually using Silness and Loe Gingival index.
Time frame: Baseline, 6-weeks, 4-months, and 6-months
Plaque Levels
Plaque levels will be evaluated using the Quigley and Hein plaque index.
Time frame: Baseline, 6-weeks, 4-months, and 6-months
Esthetic Outcomes
Visual analog scale questionnaire will be completed consisting of 5 to 6 questions at each appointment.
Time frame: 1-week, 2-weeks, 4-weeks, and 6-months