Inhaled Nebulized Tobramycin in Non-cystic Fibrosis Bronchiectasis

Inclusion Criteria: 1. Age ≥ 18 years 2. The presence of chronic respiratory symptoms such as cough, dyspnoea, expectoration of sputum 3. Confirmed non-CF bronchiectasis by (HR)CT 4. Documented history of at least 2 pulmonary exacerbations treated with courses of antibiotics within 12 months before inclusion. 5. No course of antibiotics or maintenance antibiotics (except for macrolides) 1 month prior to the start of the study. 6. Minimal one documented sputum or BAL-fluid culture with gram-negative bacteria or S.aureus within 12 months. 7. Growth of protocol defined pathogens in sputum at screening visit sensitive to tobramycin 8. Tolerance of inhaled tobramycin Exclusion Criteria: 1. Any exacerbation within the month prior to the start of the study 2. Diagnosis of cystic fibrosis 3. Active allergic bronchopulmonary aspergillosis (ABPA) 4. Any oral, IV or inhaled antibiotics (except for macrolides) within 1 month prior to the start of the study 5. Any IV or IM corticosteroids or change in oral corticosteroids (\> 10 mg) within 1 month prior to the start of the study 6. Any change/start treatment regimens macrolides, hypertonic saline, inhaled mannitol or other mucolytics, corticosteroids within 1 month prior to the start of the study 7. Change in physiotherapy technique or schedule within 1 month prior to the start of the study 8. Severe immunosuppression or active malignancy 9. Active tuberculosis 10. Chronic renal insufficiency (eGFR \< 30 ml/min), use of loop diuretics 11. Have received an investigational drug or device within 1 month prior to the start of the study 12. Serious or active medical or psychiatric illness 13. Pregnancy and child bearing 14. History of poor cooperation or non-compliance 15. Unable to use nebulizers 16. Allergic for tobramycin