Long-term Efficacy and Safety of Gabapentin Enacarbil in Japanese Restless Legs Syndrome Patients

Inclusion Criteria: * Patients who diagnosed with RLS according to the diagnostic criteria established by the International RLS Study Group * International Restless Legs Syndrome Scale (IRLS) score ≥15 presence of RLS symptoms on ≥15 days per month and ≥4 days per week preceding inclusion in this study Exclusion Criteria: * Patients using dopamine agonists or gabapentin within 1 week before or any anti-RLS treatment within 2 weeks before the start of the pretreatment observation period * Patients with an estimated creatinine clearance \<60 mL/min determined using the Cockcroft-Gault formula * Pregnant or lactating women * Individuals with serum ferritin \<20 ng/mL were also excluded from the trial * Individuals with movement disorders and/or abnormal neurological findings