Clinical Trial to Evaluate Efficacy and Safety of JOINTSTEM in Patients With Degenerative Arthritis

Inclusion Criteria: 1. Age 18 and older, male and female 2. Patients must consent in writing to participate in the study by signing and dating an informed consent document 3. Diagnosis of osteoarthritis by ACR osteoarthritis of the knee 4. Diagnosis of osteoarthritis by radiographic criteria of Kellgren and Lawrence grade 2-4 5. More than Grade 4 (0\~10 point numeric scale) pain at least for 12 weeks 6. Diagnosis of osteoarthritis of class Ⅰ\~Ⅲ by ACR(American College of Rheumatology Criteria) Global functional criteria 7. Patient who agree with contraception Exclusion Criteria: 1. Preparing for Pregnancy or Pregnant women or lactating mothers. 2. Patients with Body Mass Index (BMI) \> 35. 3. Patients with other disease including : Septic arthritis, Rheumatoid or Inflammatory joint disease, Crystalline disease (gout or pseudogout), Paget disease, Articular fractures, Ochronosis, Acromegaly, Hemochromatosis, Wilson's disease, Osteochondromatosis, Hereditary disorder 4. Patients with serious condition internal medicine disease 5. Patients with positive human immunodeficiency (HIV), hepatitis B (HBV), hepatitis C (HCV), syphilis at screening indicative of current of pass infection. 6. Patient with behavioral disorders, cognitive disorders and chronic mental symptoms 7. Patient with significant neurologic or psychiatric disorders 8. Patients who alcohol, drug abuse history 9. Patients who had participated in other clinical trials within 12 weeks prior to this study. 10. Patients who received any drug by intra-articular injection for treatment within 2 months prior to this enrollment. 11. Patients who experienced as the knee joint cartilage and stem cell therapy 12. Patients who the principal investigator considers inappropriate for the clinical trial due to any other reasons than those listed above 13. Patients who penicillin hypersensitivity reactions -