The role of surgical stress and anesthesia is unknown in the early childhood. In vitro and animal studies showed a risk for treatment with anesthesia in the developmental brain. Furthermore, stress is also an important risk factor for cognitive impairment. Therefore, the investigators want to investigate in a clinical prospective cohort study the role anesthesia and surgery on different cognitive parameters and self-controling mechanisms in children under 3 years.
In order to investigate the role of anesthesia and / or surgery on cognitive abilities the investigators want to perform a prospective cohort study in children under 3 years. Three groups should be compared: i) control without anesthesia / surgery, ii) children with only anesthesia, and iii) children with both surgery and anesthesia. All children will be investigate before and after intervention. Different behavioral scales will be used for detailed cognitive abilities and self-regulatory skills.
Study Type
OBSERVATIONAL
University of Heidelberg, Department of Anesthesiology, Heidelberg Medical School
Heidelberg, Baden-Wurttemberg, Germany
Global cognitive abilities
Bayley Scale
Time frame: 4-6 weeks
Global cognitive abilities
MONDEY (Milestone of Normal Development in Early Years) Scale
Time frame: 4-6 weeks
Global cognitive abilities
Assessment of temperament with the Infant Behavior Questionnaire Revised (IBQ-R) questionnaire
Time frame: 4-6 weeks
Global cognitive abilities
Early Childhood Behavior Questionnaire (ECBQ) questionnaire
Time frame: 4-6 weeks
surgery-associated data
reason of surgery
Time frame: 1 - 3 days
surgery-associated data
date of birth
Time frame: 1 day
surgery-associated data
length of surgery (h:min)
Time frame: 1 day
surgery-associated data
kind and quantity of anesthesia and medication (number)
Time frame: 1 day
surgery-associated data
Age (month)
Time frame: 1 day
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