Assessing Covert Consciousness in Unresponsive Patients

University of Michigan60 enrolled

Overview

In this study, the investigators explore anesthesia as a tool for providing further insight into the level of consciousness of individuals with a clinical diagnosis of unresponsive wakefulness syndrome (UWS), but who possess some neurophysiological signatures of conscious awareness. This group, who could potentially be conscious, will herein be referred to as the target population. Our goal is to assess whether or not neurological patterns of consciousness in the target population respond to anesthesia in a similar manner to neurologically compromised individuals with known consciousness (e.g. those in minimally conscious state (MCS). In healthy controls, propofol-induced unconsciousness results in an elimination of the mismatch negativity event-related brain potential (ERP) and a diminished directed connectivity. The investigators hypothesize that at doses well below those required for surgery, anesthesia will have similar effects on these neural patterns in neurologically compromised patients with the potential for conscious awareness, but will not affect these patterns in those who lack consciousness.

Study Type

INTERVENTIONAL

Allocation

NON_RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

NONE

Enrollment

Conditions

Consciousness Disorders

Interventions

Eligibility

Sex: ALLMin age: 18 YearsMax age: 50 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients admitted to the intensive care unit at Hamilton General Hospital who: * Clinical status consistent with UWS (no responsiveness to commands) * Clinical status consistent with MCS (minimal response to at least one command) * Presence of an endotracheal tube (ETT) or a tracheostomy tube * Between 18 and 50 years of age Exclusion Criteria: * • Elevated intracranial pressure (ICP) * Hepatic or renal failure * Hemodynamic instability * Active vasopressor therapy * Previous open-head injury * Previous intracranial pathology requiring neurosurgical interventions in the past 72 hours * Anticipated ICU stay \< 24 hours * Documented allergy to propofol * Pregnancy * BMI \> 35 kg/m2 * Anyone who is deemed medically unsuitable for this study by the attending intensivist * Patients who are already in a medically-induced coma for intracranial hypertension or status epilepticus

Outcomes

Primary Outcomes

Asymmetry in feedback vs. feedforward network connectivity

EEG networks will be monitored pre, during and post anesthesia. Directed connectivity will be calculated using phase lag index (PLI) and symbolic transfer entropy (STE) between all combinations of EEG sensors. Average values of feedback connectivity (e.g. from the frontal regions to parietal and occipital regions) will be compared to average values of feedforward connectivity (e.g. from parietal and occipital regions to frontal regions). Positive asymmetry will be correlated to the presence of conscious awareness and negative asymmetry will be correlated to the absence of conscious awareness.

Time frame: 3 hours

Secondary Outcomes

Presence of P300 and N400 event-related potentials

EEG signals will be processed to extract the event-related EEG reactions to the auditory stimulation paradigm. Signals will be average 300 ms post-stimuli and 400 ms post-stimuli to assess the presence of the P300 and N400 event-related potentials. Presence of these event-related potentials will be correlated to the presence of conscious awareness and absence of these event-related potentials will be correlated to the absence of conscious awareness.

Time frame: 3 hours