In Quebec, thousands of workers are concomitantly exposed to heat and chemical compounds. Exposure to heat induces physiological responses that help maintaining a stable body temperature. Those changes can affect organ functions implicated in absorption and metabolism. According to literature, those changes could lead to increased concentrations of chemical compounds in the body and their toxicity. Therefore, the aim of this study is to evaluate the pulmonary absorption and toxicokinetics of 3 organic solvents in heat stress conditions in volunteers exposed in a inhalation chamber. Results will then be used to develop PBPK models that will allow to predict organic solvent kinetics when coexposed with heat.
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
PREVENTION
Masking
NONE
Enrollment
5
4h exposure to heat (WBGT of 21°C), no solvent
4h exposure to heat (WBGT of 25°C), no solvent
4h exposure to heat (WBGT of 30°C), no solvent
4h exposure to heat (WBGT of 21°C) + Toluene (concentration = TLV)
4h exposure to heat (WBGT of 25°C) + Toluene (concentration = TLV)
4h exposure to heat (WBGT of 30°C) + Toluene (concentration = TLV)
4h exposure to heat (WBGT of 21°C) + Acetone (concentration = TLV)
4h exposure to heat (WBGT of 25°C) + Acetone (concentration = TLV)
4h exposure to heat (WBGT of 30°C) + Acetone (concentration = TLV)
4h exposure to heat (WBGT of 21°C) + Dichloromethane (concentration = TLV)
4h exposure to heat (WBGT of 25°C) + Dichloromethane (concentration = TLV)
4h exposure to heat (WBGT of 30°C) + Dichloromethane (concentration = TLV)
4h exposure to heat (WBGT of 21°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.
4h exposure to heat (WBGT of 25°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.
4h exposure to heat (WBGT of 30°C) + Toluene (concentration = TLV), participants breath normal air through a mask for evaluation of dermal absorption.
Université de Montréal
Montreal, Quebec, Canada
RECRUITINGRespiratory rate
Respiratory rate will be monitored continuously for 4hour with a respirometer
Time frame: 4hour
Cardiac frequency
Cardiac frequency will be monitored continuously for 4hour with a respirometer
Time frame: 4hour
Minute ventilation
Minute ventilation will be monitored continuously for 4hour with a respirometer
Time frame: 4hour
Tidal volume
Tidal volume will be monitored continuously for 4hour with a respirometer
Time frame: 4hour
Solvent in blood
Solvents concentrations will be measured in blood samples collected at different times (t=0, 2, 4 and 4.5hour).
Time frame: 4,5hour
Solvent or metabolite in urine
Solvent or metabolite concentrations (o-cresol for toluene exposures) will be measured for urine samples collected at different times (t=0, 4, 10 and 18hour).
Time frame: 18hour
Solvent in exhaled air
Solvents concentrations will be measured in exhaled air samples collected at different times (t=0, 1.5, 3, 4.5 and 6hour).
Time frame: 6hour
Oxygen consumption
oxygen consumption will be monitored continuously for 4hour with a respirometer
Time frame: 4hour
Carbonic dioxide production
carbonic dioxide production will be monitored continuously for 4hour with a respirometer
Time frame: 4hour
Body temperature
Body temperature is monitored continuously by telemetry
Time frame: 4hour
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