Design: prospective cohort study. Setting: Tertiary university-affiliated ART and oncology centers. Patients: 20 cancer survivors who underwent ovarian transplantation of frozen-thawed ovarian tissue, with the aim to conceive. Interventions: Ovarian tissue cryopreservation (OTCP) and transplantation, endocrine monitoring, IVF.
Main Outcomes expected: Endocrine profile IVF results, pregnancy rates following transplantation of ovarian tissue live-births rates following transplantation of ovarian tissue cancer disease recurrence
Study Type
INTERVENTIONAL
Allocation
NA
Purpose
TREATMENT
Masking
NONE
Enrollment
20
operation(mini laparotomy) for transplantation of frozen- thawed ovarian tissue
menstrual bleeding (yes/no)
recurrence of menstrual bleeding- yes or no
Time frame: up to one year
number of oocytes per IVF cycle
number of aspirated oovytes per one IVF cycle performed
Time frame: through study completion (up to 11 years following transplantation)
pregnancies
spontaneous or post IVF pregnancy rates (%)
Time frame: through study completion (up to 11 years following transplantation)
live births
live birth rates (%)
Time frame: through study completion (up to 11 years following transplantation)
disease reccurence
incidence of cancer disease recurrence
Time frame: through study completion (7 months to 141 months following transplantation)
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