Bioequivalence Study of Torrent Pharmaceuticals Ltd.'s Esomeprazole Magnesium DR Capsules Under Fasting Conditions

Inclusion Criteria: * Sex: male * Age: 18-45 years * Volunteer with BMI of 18-27 (inclusive both) kg/m2 with minimum of 50 kg weight. * Healthy and willing to participate in the study. * Volunteer willing to adhere to the protocol requirements and to provide written informed consent. * Non-smokers or smoker who smokes less than 10 cigarettes per day. Exclusion Criteria: * Inability to communicate or co-operate. * Administration of any study drug in the period 0 to 3 months before entry to the study, * History of significant blood loss due to any reason, including blood donation in the past 3 months. * Volunteers suffering from any chronic illness such as arthritis, asthma etc. * History of pre-existing bleeding disorder. * Clinically relevant abnormalities in the results of the laboratory screening evaluation. * Clinically significant abnormal ECG or Chest X-ray. * HIV, HCV, HBsAg positive volunteers. * History of alcohol or drug abuse. * History of consumption of prescribed medication since last 14days or OTC medication/ herbal remedies since last 7 days before beginning of the study. Positive to Breath alcohol test. * Opiate, tetra hydrocannabinol, amphetamine, barbiturates, benzodiazepines, Cocaine positive volunteers based on urine test. * Systolic blood pressure less than 100 mmHg or more than 140 mmHg and diastolic blood pressure less than 60 mm Hg or more than 90 mm Hg. * Pulse rate less than 50/minute or more than 100/minute. * Oral temperature less than 95°F or more than 98.6°F. * Respiratory rate less than 12/minute or more than 20/minute. * History of allergy to the test drug or any drug chemically similar to the drug under investigation. * Recent History of kidney or liver dysfunction. * Volunteers suffering from any psychiatric (acute or chronic) disorder. * Existence of any surgical or medical condition, which, in the judgment of the Chief Investigator and/or clinical investigator/physician, might interfere with the absorption; distribution,· metabolism or excretion of the drug or likely to compromise the safety of Volunteers.