Midluteal single endometrial strip will be taken using a Novak curett under general anasthesia to avoid discomfort and cramping and to proceed to cervical dilatation in case of forbidden cervix, the step that will be beneficial to embryo transfer procedure. Controller ovarian hyperstimulation; will be done using the long luteal phase agonist protocol and the short protocol(as judged by patient,s age ovarian reserve judged by day 3 FSH and antral follicular count and previous history of ovarian response). Ovarian response will be monitored by vaginal ultrasound and HCG will be given when when there is \>=1 follicle \>=18 mm. and \>=3 follicles \>=16 mm. Ultasound guided oocyte retrieval will be carried out 35 hours later. Embryo transfer will be performed on day 2 or day 3 after oocyt retrieval according to number and quality of embryos. Embryo transfer will be carried out under trans-abdominal ultrasound guidance pregnancy test will be done using qualitative blood HCG detection 2 weeks after the embryo transfer.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Enrollment
300
midluteal single endometrial strip will be taken using a Novak curett under general anasthesia to avoid discomfort and cramping and to proceed to cervical dilatation in case of forbidden cervix
Kasr Alainy medical school
Cairo, Egypt
implantation rate
number of sacs identifiable through ultrasonography divided by the number of embryos transferred
Time frame: 14 days after embryo transfer
clinical pregnancy rate
the detection of fetal cardiac activity within a gestational sac on ultrasonography examination
Time frame: 4 weeks after embryo transfer
multiple pregnancy rate
number of patients who had a multifetal pregnancy divided by the total number of clinical pregnancies
Time frame: 4 weeks after embryo transfer
abortion rate
number of patients who had a spontaneous abortion before 12 weeks of pregnancy divided by total number of clinical pregnancies
Time frame: 12 weeks of gestational age
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