Impact of Aging on Cytokine Production by Innate Immune Cells

Inclusion Criteria: * volunteers will be invited to settle an appointment with the Nice University Hospital (CHU de Nice) Research Clinical Center (CRC). * being between 18 and 30 year-old (group Y) or being older than 55 year-old (group O), * ability to understand and speak French, * being registered at the Social Security, * acceptance to be serologically tested for HIV and HVC, * considered healthy based on both past medical records and the clinical examination performed at the inclusion visit, * exhibiting a body mass index (body mass divided by the square of their height) comprised between 18.5 and 30.0 kg/m2. Exclusion Criteria: * having participated to a drug clinical trial since less than 3 months, * having traveled to a tropical or a sub-tropical country over the past 3 months, * being pregnant or a lactating mother (for women), * having performed intensive physical exercise over the past 12 hours, * following a specific diet for medical reasons, * over-drinking, i.e. more that 50 g of pure alcohol every day, * having taken an immuno-suppressive or immuno-modulatory drug over the past two weeks, or for at least 14 consecutive days over the past 6 months, * having been vaccinated over the past 3 months, * declaring not being on an empty stomach for less than 12 hours, * having received a blood transfusion or intravenous immunoglobulins over the past 3 months, * declaring being HIV- or HVC- positive, * having suffered from an infection since less than 3 weeks, * exhibiting a positive urine pregnancy test at the inclusion visit, * suffering from a severe/chronic/relapsing pathology, i.e. inflammatory bowel disease, psoriasis, atopic dermatitis, rheumatoid arthritis, multiple sclerosis, type I or type II diabetes, Parkinson's disease, and (p) having been diagnosed with a cancer and not being in a remitting period for less than 5 years.