Anisakidae frequently infect fish species that are commonly eaten by humans. Some of them are recognized as zoonotic agents, and have a high impact on human health. Infestation results from the ingestion of living larvae from contaminated fishes. It can be asymptomatic or symptomatic, resulting in acute gastric, acute intestinal or chronic forms. Allergic manifestations are frequently encountered in gastric forms, but isolated allergic symptoms can occur after ingestion of Anisakidae antigens in raw or cooked fish. Cutaneous contact or Anisakis allergen inhalation have also been reported to induce allergy/anaphylactic reactions or sensitization in the occupational setting in Spain, Italy, Sicilia or South Africa. But no data is available in France. In this context, the investigators propose to determine and compare the frequency and characteristics of fish allergy in fish workers (fishermen and fish-processing factory workers) and a control population of workers without occupational exposure to fish, in Boulogne-sur-Mer, which is an important fishing port in France, and the first European center for fish processing.
162 fishermen, 162 fish-processing factory workers, and 162 control subjects will be consecutively recruited by their occupational doctor during a routine consultation. A standardized questionnaire will be used to collect epidemiological and clinical data on potential allergic manifestation resulting from digestive, cutaneous, or respiratory contact with fish. Domestic and occupational risk factors for fish and Anisakis exposure will also be collected for both allergic and non-allergic patients.
Study Type
OBSERVATIONAL
Enrollment
486
A questionnaire will be completed in order to collect data on: * Potential allergic manifestations after fish contact: asthma, allergic rhinitis, conjunctivitis, chronic or acute urticaria, dermatitis/eczema, or severe allergic manifestations (angioedema, bronchospasm, anaphylaxis), * Occupational and/or domestic exposure to fish.
Centre ASTIL
Boulogne-sur-Mer, France
Service de Santé des Gens de Mer
Boulogne-sur-Mer, France
CHRU
Lille, France
The prevalence of fish allergy
Difference in the prevalence of fish allergy between occupationally exposed (fishermen and fish-processing factory workers) and non-exposed subjects. the fish allergy is definied by clinical diagnosis based on the presence of clinical manifestations of allergy in contact with the fish ( APC)
Time frame: contact by phone during 30 min at only visit (inclusion)
Frequencies history of infections Anisakis spp.
Comparison between occupationally exposed ( E: fishermen and fish-processing factory workers) and non-exposed subjects(NE)
Time frame: contact by phone during 30 min at only visit (inclusion)
Frequency of fish allergies, history of infections Anisakis spp. (clinical diagnosis)
comparison between occupationally exposed and non-exposed subjects for previous Anisakidosis. Fish exposure will be determined taking into account the handled fish species and the local prevalences of fish parasites.
Time frame: contact by phone during 30 min at only visit (inclusion)
history of infections Anisakis spp. (clinical diagnosis)
comparison between occupationally exposed and non-exposed subjects for previous Anisakidosis. Fish exposure will be determined taking into account the handled fish species and the local prevalences of fish parasites.
Time frame: contact by phone during 30 min at only visit (inclusion)
Frequency of risk factors for occupational or domestic exposure to fish:
comparison subjects (i) allergic or non-allergic Fish (APC + APC-vs) (ii) with or without a history of infection Anisakis spp. (IA + vs IA-).
Time frame: contact by phone during 30 min at only visit (inclusion)
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.