Growth Hormones and Cells in Human Milk Depending on Gestational Age

University Hospital of Cologne43 enrolled

Overview

Human breast milk contains growth factors including neurotrophins and cells with neuroprotective potential. Concerning growth factors milk of preterms differs significantly from term milk. The aim of this study is to give a profile of human milk concerning non-nutritive factors depending on gestational age and lactation phase.

Neurotrophins (epidermal growth factor (EGF), vascular endothelial growth factor (VEGF), nerve growth factor (NGF), brain derived neurotrophic factor (BDNF)) as well as amount of cells, especially positive for sex-determining transformer protein (TRA)-1-81 and stage-specific embryonic antigen (SSEA)-4, are planned to be quantified in human breast milk of extremely preterm newborns as well as term newborns at different stages of lactation.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Lactation

Eligibility

Sex: FEMALEMin age: 18 YearsHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: * the newborn infant is being fed with own mothers milk Exclusion Criteria: * low amount of breast milk

Locations (1)

Neonatology at the University Hospital of Cologne

Cologne, Germany

Outcomes

Primary Outcomes

neurotrophins composition

Concentration of Neurotrophins EGF, VEGF, NGF, BDNF in the human milk

Time frame: day 7

Secondary Outcomes

Amount of cells positive for surface markers TRA-1-81 and SSEA-4

surface markers characteristic for pluripotent stem cells

Time frame: day 7

Data from ClinicalTrials.gov

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