Fixed-dose Combination of Valsartan + Rosuvastatin Versus Their Isolated Components for Hypertension and Dyslipidemia.

Inclusion Criteria: * Participants of both sexes aged between 18 and 65 years; * Participants diagnosed with uncontrolled hypertension; * Participants with intermediate and high risk dyslipidemia, according to the V Brazilian Guidelines on Dyslipidemia and Prevention of Atherosclerosis; * Ability to understand and consent to participate in this clinical study, manifested by signing the Informed Consent and Informed ( IC) . Exclusion Criteria: * Participants with a previous diagnosis of familial hypercholesterolemia (homozygous); * Concomitant use of angiotensin II receptor blocker (ARB) or inhibitor of angiotensin converting enzyme (ACE); * participants with isolated hypertriglyceridemia (TG ≥150 mg / dL) according to V Brazilian Guidelines on Dyslipidemia and Prevention of Atherosclerosis; * research participants with total cholesterol (TC) above 500 mg / dL or triglyceride (TG) above 400 mg / dL; * participants with systolic blood pressure ≥180 mmHg or diastolic ≥110 mmHg; * research participants with postural hypotension (SBP decrease ≥20 mmHg or DBP ≥10 mmHg in orthostatic position in relation to the sitting position); * History of congestive heart failure (CHF) functional class III or IV (NYHA);; * any clinical, laboratory and electrocardiographic that, in the judgment of the investigator, may interfere with the safety of research participants; * Creatine phosphokinase (CPK) levels above the established laboratory normal range; * Transaminases (ALT and ASL) serum above 2 times the established laboratory normal range; * Body mass index (BMI) ≥35 kg / m²; * Immunocompromised participants (eg .: malignancies, patients with Acquired Immunodeficiency Syndrome etc); * Chronic use of drugs that may interact with the drugs of the study; * Patients on concomitant lipid-lowering therapy; * History hypersensitivity to the active ingredients used in the study; * Participants who are pregnant, nursing or planning to become pregnant, or female participants of childbearing potential who are not using a reliable method of contraception; * History of alcohol abuse or illicit drug use; * Adherence to uniformization medication \<80%; * Participating in the research that has participated in clinical trial protocols in the last twelve (12) months (CNS Resolution 251 of August 7, 1997, Part III, sub-item J), unless the investigator considers that there may be direct benefit to it;