Influence of Severe Heart Failure to Function and Molecular Biological Parameters of Catabolism in the Human Diaphragm and Peripheral Skeletal Muscle

Norman Mangner44 enrolled

Overview

Project aim is to quantify the influence of a severe therapy-refractory heart failure caused by ischemic or dilative myocardiopathy on the function of the diaphragm, its molecular biological parameters and on the M. vastus lateralis. The control group consists of patients with coronary artery disease (CAD) and normal left ventricular ejection fraction indicated for coronary artery bypass graft surgery (CABG) Differences in the geneses of heart failure (ischemic vs. dilative cardiomyopathy) will be evaluated during analysis. The ubiquitin-proteasome signaling pathway is considered as a central issue for the mechanism of the analyses muscle catabolism.

Study Type

OBSERVATIONAL

Enrollment

Conditions

Heart Failure Ischemic Myocardiopathy Dilatative Myocardiopathy

Interventions

Biopsy of the diaphragmatic muscle

Eligibility

Sex: ALLMin age: 40 YearsMax age: 70 Years

Medical Language ↔ Plain English

Inclusion Criteria: inclusion criteria Group A: * age 40 - 70 years * Restricted left ventricular pump function left ventricular ejection fraction (LVEF) \> 35% on the basis of ischemic cardiomyopathy (ICM) and restricted resting cardiac output (CI\> 2.4 L / min / m²) * or restricted maximal oxygen uptake (VO2max\> 17 ml / min / m²) * Duration of heart failure\> 1 year * Maximum of individual heart failure therapy * Heart team decision to LVAD Implantation inclusion criteria Group B: * age 40 - 70 years * Restricted left ventricular pump function (LVEF) \> 35% on the basis of dilatative cardiomyopathy (DCM) and restricted resting cardiac output (CI\> 2.4 L / min / m²) * or restricted maximal oxygen uptake (VO2max\> 17 ml / min / m²) * Duration of heart failure\> 1 year * Maximum of individual heart failure therapy * Heart team decision to LVAD Implantation inclusion criteria Group C: * age 40 - 70 years * coronary heart disease with indication for elective, coronary artery bypass surgery * normal left ventricle (LV) pumping function LVEF\> 50% * stable clinical situation (no cardiac decompensation within the last 6 months) Exclusion Criteria: * Mechanical ventilation within the last 3 months * Forced Expiratory Pressure (FEV1) \<70% of the norm and / or therapy with α antagonists, β-mimetics or inhaled corticosteroids for the treatment of a lung disease * Pulmonary fibrosis * elevated diaphragm in the ultrasound or X-ray diagnosis or known paresis of the phrenic nerve * chronic kidney disease (CKD) stage 4 and 5, i.e. glomerular filtration rate (GFR) \<30ml / min / 1.73m and / or dialysis * Acute renal failure * Treatment with immunosuppressive agents * Hepatic insufficiency Child-Pugh B and C * Higher grade ventricular arrhythmias (Lown IV b) * Acute myocardial infarction (less than three months) * Decompensated Vitium cordis * Age \<40 years and\> 70 years * Pregnancy