The Effect of Sildenafil Citrate on the Success Rate of Ovulation Induction Using Clomiphene

Ain Shams University210 enrolled

Overview

The aim of the study is to evaluate the effect of sildenafil citrate on the pregnancy rate in women undergoing induction of ovulation using clomiphene citrate.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

SINGLE

Enrollment

210

Conditions

Anovulatory

Interventions

Sildenafil & clomiphene citrateDRUG

105 Patients will receive 25 mg sildenafil citrate 6hourly orally (day 6 to the end of the cycle), and clomiphene citrate 100 mg/day (day 2 to 6) orally by the patient, for induction of ovulation

clomiphene onlyDRUG

105 Patients will receive clomiphene citrate 100 mg/day (day 2 to 6) orally by the patient, for induction of ovulation

Eligibility

Sex: FEMALEMin age: 21 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Women age 21-35 years. * Anovulatory cycles due to polycystic ovaries syndrome. * Non-smokers. * Free of major medical illness Exclusion Criteria: * Women with myoma or adenomyosis * Women with congenital uterine anomaly. * Chronic use of any medications including non-steroidal anti-inflammatory drugs. * Associated cases of infertility other than PCOs (male factor, tubal factor,….). * Asherman syndrome. * Cases with endometrial hyperplasia. * Cases with endometrial polyp

Outcomes

Primary Outcomes

Clinical pregnancy rate

Time frame: 6 weeks

Secondary Outcomes

endometrial thickness

Time frame: 2 weeks

miscarriage rate

Time frame: 13 weeks

ectopic pregnancy rate

Time frame: 8 weeks

Side Effects of Vasodilators

Time frame: 4 weeks

Data from ClinicalTrials.gov

This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.