The purpose of this research is to examine the effects of exercise of different intensities on psychological, physiological, biochemical, physiological and alcohol-related parameters in individuals with alcohol use disorders (heavy drinkers and alcoholic patients) in order to investigate possible biochemical mechanisms by which exercise may be a healthy alternative to alcohol abuse. For that purpose, a control group of individuals that do not exceed the limits for moderate alcohol use will be included.
The mechanism of incentives that lead people to unhealthy habits such as excessive alcohol consumption is not only social, personal, and psychological, but also associated with neurochemical and neurobiological mechanisms. Several programs have been developed to stop excessive drinking, but the success rates are small, while the relapse rates are very high, reaching up to 90%. Although there is some evidence for the beneficial effects of exercise on alcohol use disorders (AUDs), research is limited. The present study investigates whether exercise could be a safe adjunct therapy for alcohol abuse cessation, and the possible mechanisms involved. One of the basic assumptions is that the appropriate form of exercise in individuals with AUDs will contribute to the secretion of beta-endorphin, which in combination with psychological pleasure, vitality, change of mood, reduced stress, increased confidence, and the shift of attention will help people to follow healthy lifestyles and abhor alcohol. The research project is divided in three phases. In the first phase, (current study) the effect of acute exercise in critical psychological, physiological, biochemical and alcohol-related parameters associated with excessive alcohol consumption will be examined. In the second phase, a long-term exercise program in conjunction with psychological support strategies aimed at alcohol abuse cessation will be developed, implemented and evaluated. Finally, in the third phase, based on the results of the previous phases, awareness programs in adolescent and adult populations will be designed and implemented as well as the dissemination of results and evaluation of the project will take place.
Study Type
INTERVENTIONAL
Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
13
A group of heavy drinkers and a group of healthy controls (individuals without alcohol use disorders) will cycle on a cycle ergometer for 30 min at 50-60% of HRR. Before and immediately after exercise blood will be drawn and psychological and physiological parameters will be measured.
A group of alcoholic patients (10-14 days after detoxification) and a group of healthy controls (individuals without alcohol use disorders) will cycle on a cycle ergometer for 30 min at 55-60% of HRmax. Before and immediately after exercise blood will be drawn and psychological and physiological parameters will be measured.
Changes in Urge to drink score
According to questionnaire
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Beta-endorphin levels
Measured by radioimmunoassay (RIA)
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Cortisol levels
Measured by radioimmunoassay (RIA)
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Adrenocorticotrophic hormone (ACTH) levels
Measured by radioimmunoassay (RIA)
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Catecholamines (epinephrine, norepinephrine, dopamine) levels
Measured by radioimmunoassay (RIA)
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in C-reactive protein (CRP) levels
Semi-quantitative estimation with CRP Latex test kit
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Complete blood count values
Autoanalyzer
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Lactic acid levels
Measured using photometry
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Erythrocyte sedimentation rate (ESR) values
Wintrobe Method
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in γ-Glutamyltransferase (GGT) levels
Measured with commercial kit
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Aspartate Aminotransferase (AST) levels
Measured with commercial kit
Time frame: Before (0 min) and after exercise trial (30 min)
Changes in Alanine Aminotransferase (ALT) levels
Measured with commercial kit
Time frame: Before (0 min) and after exercise trial (30 min)
Sit and reach flexibility test for the hamstrings muscles and lower back
Each participant sits on the floor with legs stretched out straight ahead, reaches out and holds that position for at 1-2 seconds while the distance is recorded.
Time frame: Before trial (baseline)
Grip strength
Handgrip strength test
Time frame: Before trial (baseline)
Number of push-ups performed in one minute
Time frame: Before trial (baseline)
Number of sit-ups performed until exhaustion
Time frame: Before trial (baseline)
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