Proof of Concept, Twice Daily Applications of LEO 124249 Ointment in the Treatment of Chronic Hand Eczema

Inclusion Criteria: * Clinical diagnosis of chronic hand eczema with or without atopic etiology/background with a history of not adequately controlled disease activity with cutaneously applied steroid * Physician's Global Assessment of disease severity graded as at least mild at Visit 1 * In overall good health including well controlled diseases Exclusion Criteria: * Systemic treatment with immunosuppressive drugs (e.g. methotrexate, cyclosporine, azathioprine), retinoids (e.g. alitretinoin) or corticosteroids within 6 weeks prior to randomization (inhaled or intra-nasal steroids corresponding to up to 1 mg prednisone for asthma or rhinitis may be used). * PUVA (Psoralen Ultraviolet A) or UVB (Ultraviolet B) therapy on the hands within 4 weeks prior to randomization * Cutaneously applied treatment with immunomodulators (pimecrolimus, tacrolimus) or corticosteroids on the hands within 2 weeks prior to randomization. * Use of systemic antibiotics or cutaneously applied antibiotics on the hands within 2 weeks prior to randomization * Concurrent skin diseases on the hands * Current diagnosis of exfoliative dermatitis * Significant clinical infection (impetiginized hand eczema) on the hands which requires antibiotic treatment * A marked abnormal ECG at baseline * Known hepatic dysfunction or hepatic dysfunction tested at Screening * Current participation in any other interventional clinical trial