Evaluation of Two Pharmacological Protocols for Pre-emptive Analgesia in Impacted Third Molar Surgery

Federal University of the Valleys of Jequitinhonha and Mucuri18 enrolled

Overview

The main aim of the study is to investigate the pre-emptive effect of dexamethasone and diclofenac associated to codeine to prevent the pain, edema and limited mouth opening at the extraction of third molar.

The surgery of third molar is usually associated with important post-surgical sequelae. The damage caused to tissue and bone may result in considerable pain, edema and trismus. The symptoms start gradually, peaking in 2 days after the extraction. The use of medications such as dexamethasone and diclofenac associated to codeine may support the prevention of post-surgical pain. This clinical trial aim compare the the pre-emptive effect of dexamethasone and diclofenac associated to codeine to prevent the pain, edema and limited mouth opening at the extraction of third molar.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

DOUBLE

Enrollment

Conditions

Pain Edema Trismus

Interventions

DexamethasoneDRUG

Dexamethasone 8 mg

Diclofenac Sodium associated with CodeineDRUG

Diclofenac Sodium 50 mg associated with Codeine 50 mg

Eligibility

Sex: ALLMin age: 18 YearsMax age: 35 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patients with indication of asymptomatic bilateral extractions of lower third molars; * Aged 18 years or older; * Have a good health and no disease; Exclusion Criteria: * Patients with history of any medication treatment within 15 days before the beginning of the research, history of allergy to the drugs, substances or materials used in this study, pregnancy or lactation.

Locations (1)

Universidade Federal dos Vales do Jequitinhonha e Mucuri

Diamantina, Minas Gerais, Brazil

Outcomes

Primary Outcomes

Post-surgical swelling of third molar extraction determined using linear measures in the face

During the post-surgical intervals of 24, 48 and 72 hours and seven days, the swelling was determined using linear measures in the face.