Photodynamic Therapy During Supportive Periodontal Therapy

National University of Singapore27 enrolled

Overview

27 subjects on SPT, each with at least two residual pockets ≥5mm, were recruited for this randomised, split-mouth controlled trial, providing a total of 72 sites. At baseline, probing pocket depth (PPD), recession, clinical attachment level (CAL), plaque and bleeding on probing (BOP) of all sites were examined. Gingival crevicular fluid (GCF) were collected to determine level of cytokines IL-1β, -6, -8, TNF-α and MMP-8 via ELISA. Control sites received subgingival instrumentation and rubber cup polishing with pumice. In addition test sites received a single application of PDT using Fotosan® and photosensitizer consisting of toludine blue O solution. The subjects were recalled three and six months later and re-examined. Site level analysis was performed.

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

TREATMENT

Masking

NONE

Enrollment

Conditions

Periodontal Diseases Chronic Periodontitis Periodontal Attachment Loss

Fotosan 630, CMS Dental, Copenhagen, DenmarkDEVICE

The PDT system consists of a hand-held rechargeable light-emitting diode (LED) light source (Fotosan® 630 device, CMS Dental, Copenhagen, Denmark) and 0.1 mg/mL toluidine blue photosensitiser. The LED light source has a wavelength between 620 to 640 nm and peak of 630 nm and a power density between 2000 to 4000 mW/cm2.

Scaling and root planingOTHER

Scaling and root debridement of the residual pockets were performed using ultrasonic device and hand curettes until root surfaces felt hard and smooth. The sites were then polished using rubber cup and prophylaxis paste.

Eligibility

Sex: ALLHealthy volunteers:

Medical Language ↔ Plain English

Inclusion Criteria: 1. Good general health with no systemic diseases causing manifestation of periodontal diseases 2. Age ≥ 21 years 3. History of chronic periodontitis 4. At least two residual PPD ≥ 5 mm with or without bleeding on probing 5. Compliant with recalls, i.e. last SPT visit at most 6 months before start of trial 6. Able to give written informed consent Exclusion Criteria: 1. Pregnant or lactating females 2. Local or systemic antibiotics intake in the past 3 months 3. Systemic conditions which could affect progression of periodontitis 4. Long term use of NSAIDs or immunosuppressive medications 5. Participation in other clinical trials

Outcomes

Primary Outcomes

Difference in percentage change in probing pocket depth

Time frame: 6 months

Secondary Outcomes

Bleeding on probing

Time frame: 6 months

Clinical attachment level

Time frame: 6 months

Recession

Time frame: 6 months

Cytokines level

Time frame: 6 months

Photodynamic Therapy During Supportive Periodontal Therapy

Overview

Conditions

Interventions

Eligibility

Outcomes

Primary Outcomes

Secondary Outcomes