Aims:To explore the consciousness stimulation role of DBS (Deep Brain Stimulation) and TMS (Transcranial Magnetic Simulation) for DOC (Disorders of Consciousness) patients. Methods:Seventy-five DOC patients will be randomised into three groups: DBS group, TMS group and Control group. Three months after treatments, the result will be analysed and concluded.
To explore the consciousness stimulation role of DBS (Deep Brain Stimulation) and TMS (Transcranial Magnetic Stimulation) for DOC (Disorders of Consciousness) patients. Seventy-five DOC patients will be randomised into three groups: DBS group, TMS group and Control group. These patients will be recorded the conscious level, fMRI (functional magnetic resonance imaging) and EEG evaluation before treatment of research, and three months later the prognosis was also recorded. Finally, the variation of consciousness, prognosis, fMRI and EEG index for three groups will be analyzed and compared. Hopefully, there will be a conclusion for these treatments to DOC patients.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Enrollment
75
Deep brain stimulation means stimulate the brain with DBS.
Transcranial magnetic stimulation means stimulate the brain with magnetic stimulation.
Means without above additional treatment.
Department of Neurosurgery, Huashan Hospital
Shanghai, Shanghai Municipality, China
RECRUITINGThe consciousness variation of DBS and TMS for DOC Patients in a large scale randomised trial (revised-coma recovery scale)
revised-coma recovery scale(CRS-R)
Time frame: 3 months
The conscious index based on fMRI
Using fMRI to evaluate consciousness in DoC patients
Time frame: 3 months
The conscious index based on EEG
Using EEG to evaluate consciousness in DoC patients
Time frame: 3 months
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