The Effect of Pregabalin on Pain of Propofol Injection

Kyungpook National University Hospital120 enrolled

Overview

Pain is a common side effect of propofol injection. The purpose of this study was to compare the efficacy of pregabalin and lidocaine in reducing propofol injection pain.

In a randomized, double blind, prospective trial, 120 patients were allocated to one of three groups (each n=40) receiving intravenous lidocaine 40mg (group L), oral pregabalin 75 mg (group LP), and oral pregabalin 150 mg (group HP) as pretreatment, followed by injection of 25% of 2 mg/kg propofol. Pain was assessed by a four point scale (0=no, 1=mild, 2=moderate, 3=severe pain).

Study Type

INTERVENTIONAL

Allocation

RANDOMIZED

Purpose

PREVENTION

Masking

QUADRUPLE

Enrollment

120

Conditions

Pain

Interventions

LidocaineDRUG

PregabalinDRUG

propofolDRUG

Eligibility

Sex: ALLMin age: 20 YearsMax age: 60 Years

Medical Language ↔ Plain English

Inclusion Criteria: * Patient underwent elective dental surgery. Exclusion Criteria: * Patient with a history of adverse response to lidocaine or pregabalin, * Patient with cardiovascular or respiratory disease, * Patient who takes any sedatives, analgesics, or anticonvulsants within 24 hours before surgery.

Locations (1)

Kyungpook National University Hospital

Daegu, South Korea

Outcomes

Primary Outcomes

Propofol injection pain

Thirty seconds after pretreatment, 25% of the total calculated dose of propofol (2 mg/kg) was administrated into a dorsal hand vein. Ten seconds after injection of propofol, pain was assessed on a four-point scale (0=none, 1 = mild, 2= moderate, 3= severe).

Time frame: 10 seconds after injection of propofol

Data from ClinicalTrials.gov

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