The aim of the study is to evaluate the incidence of severe hypoxemia episodes during the intubation procedure with two methods of pre-oxygenation: 1. NIV (Non Invasive Ventilation) 2. HFNC (High-flow nasal canula oxygen therapy)
Design: Clinical randomized, open, multicenter, comparative trial, with parallel groups aimed at evaluating a medical device. Selection of patients admitted to the ICU for acute respiratory failure, requiring endotracheal intubation. Randomized study, inclusion in two groups: NIV or HFNC. Experimental group: NHFC group, preoxygenation by NHFC: oxygen flow rate of 60 L / min and 100% FiO2. Control group: NIV group, preoxygenation by NIV: pressure support set for an exhaled tidal volume of 6-8 ml / kg of ideal body weight, PEEP of 5 cm H2O and FiO2 at 100%. Duration of participation of each patient: 28 days
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Enrollment
320
Pre-oxygenation with high-flow nasal canula oxygen therapy
Pre-oxygenation with non-invasive ventilation
CHU Angers
Angers, France
CHU La cavale Blanche
Brest, France
Severe desaturation as defined by a pulse oxymetry below 80%
drop below 80% of pulse oxymetry measurement
Time frame: through five minutes after preoxygenation period
This platform is for informational purposes only and does not constitute medical advice. Always consult a qualified healthcare professional.
CHU louis MOURIER
Colombes, France
Chu Mondor
Créteil, France
CHU Dijon
Dijon, France
CH Vendée
La Roche/Yon, France
CH La Rochelle
La Rochelle, France
CHU Lille
Lille, France
Limoges University Hospital
Limoges, France
CH St Joseph St Luc
Lyon, France
...and 17 more locations