The purpose of this study is to determine whether intrauterine hCG can improve the implantation rate and clinical pregnancy rate after embryo transfer in IVF/ICSI cycle.
Patients at infertility clinic, siriraj hospital who come to start IVF/ICSI treatment cycle or endometrial preparation for embryo transfer are consiferes as eligible subjects. On the day of embryo transfer (both fresh and frozen-thaw cycle), the subjects will be randomized to 2 groups. 1. control group: embryo transfer after intrauterine infusion with standard embryo culture media 4-7 minutes 2. study group: embryo transfer after intrauterine infusion with hCG (Pregnyl) 4-7 minutes The patients will come back for serum beta-hCG measurement 2 weeks later after embryo transfer and other 2 weeks later for transvaginal ultrasound if beta-hCG is positive.
Study Type
INTERVENTIONAL
Allocation
RANDOMIZED
Purpose
HEALTH_SERVICES_RESEARCH
Masking
DOUBLE
Enrollment
200
Infertility unit, Siriraj Hospital
Bangkok, Bangkok, Thailand
RECRUITINGClinical pregnancy rate
Transvaginal ultrasound to confirm number of intrauterine gestational sac and fetal heart beats
Time frame: 2 weeks after positive serum beta-hCG
Chemical pregnancy rate
positive serum beta-hCG more than 3
Time frame: 2 weeks after embryo transfer
Implantation rate
number of intrauterine gestational sac / number of embryo transferred
Time frame: 2 weeks after positive serum beta-hCG
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