Echocardiography, Adherence to Mediterranean Diet (AMDS) and Physical Exercise in Fatty Liver

Azienda Ospedaliera, Universitaria Policlinico Vittorio Emanuele660 enrolled

Overview

NAFLD is associated with unhealthy lifestyle and obesity, without alcohol habits. An association of NAFLD with coronary artery disease and with impaired heart function was reported, but without considering severity of NAFLD and with the bias of including diabetes. Aim: to challenge if severity of liver steatosis assessed by UltraSound Bright Liver Score (BLS) can predict the impairment of systolic heart function, assessed by echocardiography (Ejection Fraction, EF), diastolic function (assessed by E/A ratio), Left Ventricular Mass, Left atrial diameter.

METHOD and measures: Age, obesity (BMI) , dietary profile (assessed as Adherence to Mediterranean Diet Score, AMDS), physical activity profile, assessed by the Baecke's physical exercise questionnaire, Insulin resistance (assessed by HOMA) were all taken into account for their confounding and synergic effect. Multiple regression analysis and Odds ratio will be the statistical tools that will be used.Receiver operator curve (ROC) analysis will be applied in order to find the cut-off, if any, of the considered measures vs. NAFLD and significant abnormalities of echocardiography measures.

Study Type

OBSERVATIONAL

Enrollment

660

Conditions

Fatty Liver

Eligibility

Sex: ALLMin age: 18 YearsMax age: 65 Years

Medical Language ↔ Plain English

Inclusion Criteria: Clinical diagnosis on fatty liver Exclusion Criteria: * Diabetes * Cancer * virus hepatitis * alcohol habits above 20 g/day (140 g/week) and any binge drinking * myocardial infarction, * valvular or congenital heart disease * heart failure * respiratory or renal insufficiency * rheumatic or autoimmune disease.

Locations (1)

Outcomes

Primary Outcomes

Left Ventricular Myocardial mass: the measurement described below is echo-cardiographic, taken according to the joint guidelines of the American and European Societies of Echocardiography with appropriate equipments.

left ventricular mass indexed by body surface area g/m2.

Time frame: through study completion, an average of 4 years

Secondary Outcomes

assessment of diastolic function: the measurement described below is echo-cardiographic, taken according to the joint guidelines of the American and European Societies of Echocardiography with appropriate equipments.

Doppler transmitral E/A ratio

Time frame: through study completion, an average of 4 years

assessment of systolic function: the measurement described below is echo-cardiographic, taken according to the joint guidelines of the American and European Societies of Echocardiography with appropriate equipments.

ejection fraction (%)

Time frame: through study completion, an average of 4 years